- Diagnostic molecular pathology, part 2: Proteomics and clinical applications of molecular diagnostics in hematopathology
This is the second part of a review article dedicated to diagnostic molecular pathology. It has a more in-depth discussion in the advances in the field of “proteomics” and their role in diagnosis, prognostication, and clinical management of lymphoid and leukemic neoplasms. The article also addresses the crucial role of molecular diagnostics in monitoring engraftment status following marrow transplantation.
- Diagnostic molecular pathology: current techniques and clinical applications, part I
This is the first part of a review article dedicated to diagnostic molecular pathology. It has a more in-depth discussion of the different diagnostic techniques. Recent revolutionary progress in human genomics is reshaping our approach to therapy and diagnosis. Nucleic acid–based testing is becoming a crucial diagnostic tool not only in the setting of inherited genetic disease, but in a wide variety of neoplastic and infectious processes. Following diagnosis, molecular testing can help guide appropriate therapy by identifying specific therapeutic targets of several newly tailored drugs, thus pharmacogenomics. Molecular diagnostics provides the necessary underpinnings for any successful application of gene therapy or biologic response modifiers. It offers a great tool for assessing disease prognosis and therapy response and detecting minimal residual disease. It is estimated that by the year 2005, more than 5% of all laboratory testing will be based on DNA or RNA analysis
A comprehensive, fun and entertaining site devoted exclusively to histology. Learning histology was never so enjoyable! This site includes one of the largest collections of histology photomicrographs on the internet.
- Anatomy Atlases
A digital library of anatomy information. Its purpose is to educate medical students and physicians on anatomy.
CME Sites (with Credits)
- Pathology Case Studies
Case Studies The Department of Pathology at University of Pittsburgh School of Medicine has formatted many pathology cases for online viewing
- Gray Anatomy
Gray Anatomy online
- Molecular Pathology Resource Guide
The Molecular Pathology Resource Guide is one of four CAP Resource Guides that brings a collected set of resources together in one place that are focused on a specific hot-topic technology important to pathologists. Each comprehensive guide highlights current resources such as a curated set of journal articles, and a collected set of CAP resources that includes learning opportunities, proficiency testing, and accreditation related to this technology. Also, each Resource Guide includes an “Insights From Adopters” section to gain perspective from pathology leaders in the field. In sum, each Resource Guide provides a one-stop resource that will assist busy pathologists to find valuable information about a dynamic and important emerging technology
- Introduction to molecular diagnostics: The Essential of Diagnotics Series
This resource serves as an overview of the molecular diagnostic techniques that are currently used in molecular pathology. The techniques detect and measure the presence of genetic materials associated with specific disease conditions, to help uncover the underlying mechanisms of disease conditions. This in turn allow clinicians to tailor care for individual, facilitating the practice of “personalized medicine”. The report outlines Polymerase Chain Reaction (PCR) and other amplification methods are developed into powerful clinical diagnostic technologies. These diagnostics has become important decision making tools in different stages of patient care -- risk assessment, screening, diagnosis, staging and prognosis, therapy selection and monitoring. With each stage, a specific example was described to give an entry-level knowledge to frontline doctors for better understanding of different diagnostic techniques, their applications and the individual characteristics.
- Pathology outlines weekly online case conference
Pathology Outlines offer online free clinicopathologic conference for interesting cases in anatomic pathology. Integration of clinical presentation, pathologic findings and representative photomicrographs are included in a concise, easy-to-understand manner.
Organizations / Associations / Institutions
- The Hong Kong Molecular Pathology Diagnostic Centre(HKMPDC)
The Hong Kong Molecular Pathology Diagnostic Centre is founded by a group of professionally qualified clinical laboratory scientists. We strive to provide affordable, authentic, and advanced molecular testing services to all patients in need and thereby promoting better patient care.
- Centre for Genomic Sciences, LKS Faculty of Medicine, HKU
The Centre for Genomic Sciences (formerly known as Genome Research Centre) was established to provide leadership in genome research in Hong Kong and the region by developing expertise and infrastructure for studies in genomics, proteomics, and bioinformatics. It also aims to facilitate the translation of knowledge into applications for the understanding of disease mechanisms and for the development of diagnostic and therapeutic measures. Resources on the latest technology, methodology and test output are updated regularly. Centre scientists are developing methodologies for studying the role of genetic variations in disease, and have identified genetic loci that contribute to Mendelian and complex disorders. The Centre is very active in outreach to promote genomics in the forms of public forums, mass media interviews, conferences, workshops, technology seminars, and education and training to students, postdoctoral fellows, scientists and clinicians.
- Treatment-focused genetic testing
Treatment-focused genetic testing is a blood test that may be considered around the time of a breast cancer diagnosis to:see if a faulty breast cancer protection gene (called BRCA1 or BRCA2) is present in order to help plan treatment.